The COVID-19 pandemic continues to evolve rapidly, causing institutions of higher education (IHEs) to evaluate and plan for numerous “what if” scenarios. These guidelines are based on information about COVID-19 that is known today. They are purposely broad for universal use and written with the understanding that not all colleges will have the resources to implement everything written in this document. IHEs should view these guidelines and evaluate the feasibility of these recommendations in the light of their own campus environment, community resources, public health capacity, demographics, internal resources, and risk tolerance. As the pandemic continues, additional guidance will be forthcoming from ACHA.